State Ledger
Company profile

Upstream Bio, Inc. CIK 2022626

Ticker
UPB (Nasdaq)
Industry
Pharmaceutical Preparations
Headquarters
Waltham, MA 02451
Fiscal year end
2025 (FY)
Market Data
Close
$4.17
Change
-$0.52
Change %
-11.09%
Volume
76,095

UPB · trading date Oct 12, 2026 · previous close $4.69 · source: Alpaca (IEX feed, not consolidated full-market data).

Key Financials
Revenue
$2.85M
Net income
-$143.44M
Total assets
$353.77M
Total liabilities
$14.00M
Stockholders' equity
$339.77M
Cash & equivalents
$101.58M
Operating income
-$160.36M
Operating cash flow
-$133.28M
Capital expenditures
$165.0K

Fiscal year 2025, via 10-K filed 2026-03-26. A dash means this figure wasn't reported in the source filing under a field State Ledger recognizes - not that the value is zero.

Financial Performance
Operating margin
-5,618.8%
Net margin
-5,026.0%
Free cash flow
-$133.44M
Free cash flow margin
-4,675.5%
Liabilities / assets
4.0%
Equity / assets
96.0%
CapEx / revenue
5.8%
Operating cash flow / net income
0.93×

Derived from the fiscal year 2025 figures above. These metrics are mathematical calculations and do not represent a rating or assessment of the company.

Financial History
Fiscal yearRevenueNet incomeAssetsLiabilitiesEquity
2025 $2.85M -$143.44M $353.77M $14.00M $339.77M
2024 $2.37M -$62.81M $481.72M $11.87M $469.85M
2023 $2.38M -$20.54M $117.20M $9.39M -$123.13M
Company Details
SIC code
2834
State of incorporation
DE
Active filer
Yes
Most recent SEC filing
Form 4
2026-09-17
Financials filed via
Form 10-K
filed 2026-03-26

"Most recent SEC filing" may differ from the filing used for the financial figures above.

Location
Waltham, MA 02451
890 WINTER STREET, SUITE 200
Data & Methodology

SEC EDGAR submissions API (identity, collected Sep 19, 2026, 15:11 UTC) and SEC XBRL Company Facts API (financials, collected Sep 26, 2026, 15:35 UTC) · figures as originally filed, not restated · a dash always means a value wasn't reported, never a real zero.

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