State Ledger
Company profile

Spyre Therapeutics, Inc. CIK 1636282

Ticker
SYRE (Nasdaq)
Industry
Pharmaceutical Preparations
Headquarters
Waltham, MA 02453
Fiscal year end
2025 (FY)
Market Data
Close
$85.86
Change
+$0.15
Change %
0.17%
Volume
68,109

SYRE · trading date Oct 12, 2026 · previous close $85.72 · source: Alpaca (IEX feed, not consolidated full-market data).

Key Financials
Revenue
$0
Net income
-$155.20M
Total assets
$777.78M
Total liabilities
$62.55M
Stockholders' equity
$715.24M
Cash & equivalents
$85.72M
Operating income
-$209.56M
Operating cash flow
-$169.25M
Capital expenditures
—

Fiscal year 2025, via 10-K filed 2026-02-19. A dash means this figure wasn't reported in the source filing under a field State Ledger recognizes - not that the value is zero.

Financial Performance
Operating margin
—
Net margin
—
Free cash flow
—
Free cash flow margin
—
Liabilities / assets
8.0%
Equity / assets
92.0%
CapEx / revenue
—
Operating cash flow / net income
1.09×

Derived from the fiscal year 2025 figures above. These metrics are mathematical calculations and do not represent a rating or assessment of the company.

Financial History
Fiscal yearRevenueNet incomeAssetsLiabilitiesEquity
2025 $0 -$155.20M $777.78M $62.55M $715.24M
2024 $0 -$208.02M $608.48M $90.68M $517.80M
2023 $886.0K -$338.79M $341.86M $73.29M $184.02M
2022 $2.33M -$83.82M $71.14M $20.84M $50.31M
2021 $18.74M -$65.80M $109.93M $25.99M $83.94M
Company Details
SIC code
2834
State of incorporation
DE
Active filer
Yes
Most recent SEC filing
Form 8-K
2026-09-08
Financials filed via
Form 10-K
filed 2026-02-19

"Most recent SEC filing" may differ from the filing used for the financial figures above.

Location
Waltham, MA 02453
221 CRESCENT STREET
Data & Methodology

SEC EDGAR submissions API (identity, collected Sep 19, 2026, 15:11 UTC) and SEC XBRL Company Facts API (financials, collected Sep 26, 2026, 15:34 UTC) · figures as originally filed, not restated · a dash always means a value wasn't reported, never a real zero.

← Back to Massachusetts — Public Companies